CAS No. 1073612-91-5

Batch: Purity:99.85
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CY-09 Chemical Structure
Chemical Structure
Check the CY-09 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1073612-91-5
Molecular Formula

C19H12F3NO3S2
Molecular Weight (MW) 423.43
SMILES C1=CC(=CC(=C1)C(F)(F)F)CN2C(=O)C(=CC3=CC=C(C=C3)C(=O)O)SC2=S

Biological Activity

CY-09 is a direct, selective NLRP3 inflammasome inhibitor that specifically binds to the ATP-binding motif of the NLRP3 NACHT domain. By blocking NLRP3 ATPase activity, CY-09 suppresses NLRP3 inflammasome oligomerization and assembly, thereby downstream preventing caspase-1 activation, interleukin-1β (IL-1β) cleavage, and pyroptosis. Publicly reported studies demonstrate that CY-09 exhibits potent anti-inflammatory effects in vivo, significantly attenuating disease severity in mouse models of gout, cryopyrin-associated periodic syndromes, and type 2 diabetes. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 85 mg/mL (200.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Jiang H, et al. J Exp Med. 2017;214(11):3219-3238.

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Note: Technical data last updated: Sep 1, 2026.