CX-5461 (Pidnarulex) Mechanism of Action: RNA Polymerase I Inhibition in Homologous Recombination Deficient Cancer Cells Research

CX-5461 (Pidnarulex) MOA：Targeting RNA Polymerase I/DNA Damage Response Pathway for Homologous Recombination Deficient (HRD) Solid Tumors

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CX-5461 (Pidnarulex) is a first-in-class, selective RNA polymerase I inhibitor. It affects ATM/ATR and p53 signaling pathways by inhibiting rDNA transcription and inducing DNA damage, effectively suppressing cancer cell proliferation and promoting apoptosis.

Primary Applications and Mechanism of Action

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