CAS No. 2408590-37-2
Batch:
Purity:99.51
Chemical Structure
Check the
CWI1-2 hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[(Z)-(5-chloro-2-hydroxyphenyl)methylideneamino]-2,3-bis[(E)-(5-chloro-2-hydroxyphenyl)methylideneamino]guanidine;hydrochloride | |
|---|---|---|
| CAS Number | 2408590-37-2 | |
| Molecular Formula |
C22H17Cl3N6O3.ClH |
|
| Molecular Weight (MW) | 556.23 | |
| InChIKey | UXAOLDYLYMMMRC-FZQKVMMRSA-N |
CWI1-2 hydrochloride is a small-molecule inhibitor of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2). It binds IGF2BP2 and disrupts its binding to N6-methyladenosine (m6A)-modified RNA transcripts, thereby impairing glutamine metabolism pathways driven by target genes such as MYC, GPT2, and SLC1A5. This pathway disruption suppresses leukemia stem cell self-renewal and induces cell differentiation and apoptosis, demonstrating anti-leukemic activity in acute myeloid leukemia. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
110 mg/mL
(197.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 11 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.