CAS No. 2815296-08-1
Batch:
Purity:97.71
Chemical Structure
Check the
CVN293
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-[7-fluoro-1-(pyridazin-3-ylmethyl)benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine | |
|---|---|---|
| CAS Number | 2815296-08-1 | |
| Molecular Formula |
C14H10FN7O |
|
| Molecular Weight (MW) | 311.27 | |
| InChIKey | ONRXHVJHFORDDI-UHFFFAOYSA-N |
Biological Activity
CVN293 is a brain-permeable small-molecule inhibitor targeting the potassium channel KCNK13. It effectively inhibits NOD-like receptor protein 3 (NLRP3) inflammasome-mediated interleukin-1β (IL-1β) production in lipopolysaccharide-stimulated primary neonatal murine microglia. Downstream modulation of the NLRP3 inflammasome signaling pathway reduces neuroinflammatory cascades and microglial activation, demonstrating potential applications in neurodegenerative research such as Alzheimer's disease. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
10 mg/mL
(32.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.