CAS No. 68341-14-0
Chemical Structure
Check the
Cu(II)GTSM
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | copper;N-methyl-N'-[2-[[methylamino(sulfido)methylidene]hydrazinylidene]ethylideneamino]carbamimidothioate | |
|---|---|---|
| CAS Number | 68341-14-0 | |
| Molecular Formula |
C6H10CuN6S2 |
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| Molecular Weight (MW) | 293.86 | |
| InChIKey | MNLAJDKBIQOELG-UHFFFAOYSA-L |
Cu(II)GTSM is a cell-permeable organometallic inhibitor of glycogen synthase kinase 3β (GSK3β). By modulating intracellular copper levels, it inhibits GSK3β activity, leading to reduced tau hyperphosphorylation and decreased accumulation of neurotoxic amyloid-beta (Aβ) oligomers and trimers. Downstream, Cu(II)GTSM mitigates Aβ-mediated neurotoxicity, restores cognitive function, and demonstrates potential therapeutic utility in anticancer and antimicrobial applications.
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Note: Technical data last updated: Sep 1, 2026.