CAS No. 1279713-77-7
Batch:
Purity:99.85
Chemical Structure
Check the
CU-CPT 4a
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R)-2-[(3-chloro-6-fluoro-1-benzothiophene-2-carbonyl)amino]-3-phenylpropanoic acid | |
|---|---|---|
| CAS Number | 1279713-77-7 | |
| Molecular Formula |
C18H13ClFNO3S |
|
| Molecular Weight (MW) | 377.82 | |
| InChIKey | IAASQMCXDRISAV-CYBMUJFWSA-N |
CU-CPT 4a is a small-molecule antagonist of Toll-like receptor 3 (TLR3) that inhibits TLR3 and double-stranded RNA-mediated signaling. By blocking receptor activation, it suppresses the downstream NF-kB signaling pathway and reduces the expression of proinflammatory cytokines such as TNF-α and IL-1β. Consequently, CU-CPT 4a serves as a valuable tool for investigating protein-RNA interactions and Toll-like receptor-mediated immune responses. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(201.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 19 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.