CAS No. 871362-31-1

Batch: Purity:99.3
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CTEP (RO4956371) Chemical Structure
Chemical Structure
Check the CTEP (RO4956371) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-chloro-4-[2-[2,5-dimethyl-1-[4-(trifluoromethoxy)phenyl]imidazol-4-yl]ethynyl]pyridine
CAS Number 871362-31-1
Molecular Formula

C19H13ClF3N3O
Molecular Weight (MW) 391.77
SMILES CC1=C(N=C(N1C2=CC=C(C=C2)OC(F)(F)F)C)C#CC3=CC(=NC=C3)Cl
InChIKey GOHCTCOGYKAJLZ-UHFFFAOYSA-N

Biological Activity

CTEP (RO4956371) is a potent, orally bioavailable allosteric antagonist of mGlu5 (IC50 of with >1000-fold selectivity over other metabotropic glutamate receptors. By blocking mGlu5 receptor signaling, CTEP inhibits downstream intracellular calcium mobilization and suppresses ERK phosphorylation. These molecular actions modulate central synaptic plasticity and effectively rescue cognitive and behavioral deficits in preclinical models of neurological disorders. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 78 mg/mL (199.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 78 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Lindemann L, et al. J Pharmacol Exp Ther. 2011;339(2):474-86.

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Note: Technical data last updated: Sep 1, 2026.