CAS No. 1661846-05-4
Batch:
Purity:99.58
Chemical Structure
Check the
CRT-0105446
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[5-[3-[4-methoxy-2-(trifluoromethyl)phenyl]-4-pyridinyl]-1,3-thiazol-2-yl]-2-methylpropanamide | |
|---|---|---|
| CAS Number | 1661846-05-4 | |
| Molecular Formula |
C20H18F3N3O2S |
|
| Molecular Weight (MW) | 421.44 | |
| InChIKey | UIQNMIISGRIHIY-UHFFFAOYSA-N |
Biological Activity
CRT-is a potent aminothiazole inhibitor targeting LIM kinase 1 (LIMK1). By suppressing LIMK1 enzymatic activity, CRT-reduces downstream expression of phosphorylated cofilin and modulates actin cytoskeletal reorganization. This targeted pathway inhibition suppresses human breast cancer cell growth in MCF-cellular models and significantly impairs tumor cell invasion in MDA-MB-231 cell lines. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
84 mg/mL
(199.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.