CAS No. 906673-24-3

Batch: Purity:98
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Crisaborole (AN2728) Chemical Structure
Chemical Structure
Check the Crisaborole (AN2728) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[(1-hydroxy-3H-2,1-benzoxaborol-5-yl)oxy]benzonitrile
CAS Number 906673-24-3
Molecular Formula

C14H10BNO3
Molecular Weight (MW) 251.05
SMILES B1(C2=C(CO1)C=C(C=C2)OC3=CC=C(C=C3)C#N)O
InChIKey USZAGAREISWJDP-UHFFFAOYSA-N

Ordering Information

Biological Activity

Crisaborole (AN2728) is a boron-based, selective phosphodiesterase 4 (PDE4) inhibitor with broad-spectrum anti-inflammatory activity. By inhibiting PDE4, Crisaborole prevents the breakdown of cyclic adenosine monophosphate (cAMP), resulting in increased intracellular cAMP levels. This elevation suppresses downstream pro-inflammatory NF-κB and cytokine signaling, decreasing the production of inflammatory cytokines such as TNF-α, IL-12, IL-23, and IFN-γ to attenuate local inflammatory responses. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL (199.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.