CAS No. 310460-39-0
Batch:
Purity:98.56
Chemical Structure
Check the
CPYPP
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (4E)-4-[(E)-3-(2-chlorophenyl)prop-2-enylidene]-1-phenylpyrazolidine-3,5-dione | |
|---|---|---|
| CAS Number | 310460-39-0 | |
| Molecular Formula |
C18H13ClN2O2 |
|
| Molecular Weight (MW) | 324.76 | |
| SMILES | C1=CC=C(C=C1)N2C(=O)C(=CC=CC3=CC=CC=C3Cl)C(=O)N2 | |
| InChIKey | VVZJFICTTKPNCK-KVDBUQHUSA-N |
CPYPP is a small-molecule inhibitor of dedicator of cytokinesis 2 (DOCK2) that targets the DHR-2 domain, inhibiting its guanine nucleotide exchange factor (GEF) activity for Rac1 with an IC50 of. By blocking DOCK2-mediated Rac activation, CPYPP suppresses downstream Rac GTPase signaling, leading to impaired lymphocyte migration and attenuated immune cell responses. CPYPP also shows inhibitory activity against DOCK180 and DOCK5. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
65 mg/mL
(200.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.