CAS No. 1446144-04-2

Batch: Purity:99.69
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CPI-203 Chemical Structure
Chemical Structure
Check the CPI-203 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetamide
CAS Number 1446144-04-2
Molecular Formula

C19H18ClN5OS
Molecular Weight (MW) 399.90
SMILES CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)N)C4=CC=C(C=C4)Cl)C
InChIKey QECMENZMDBOLDR-AWEZNQCLSA-N

Biological Activity

CPI-203 is a potent BET bromodomain inhibitor targeting BRD4. By disrupting the interaction between BET bromodomains and acetylated histones on chromatin, it suppresses transcriptional elongation of key oncogenic drivers, including MYC. This inhibition downregulates downstream proliferative signaling cascades, resulting in cell cycle arrest and suppressed growth across various hematologic and solid tumor cell lines. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 79 mg/mL (197.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 46 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Filippakopoulos P, et al. Nature. 2010;468(7327):1067-73.

[2] Shi J, et al. Mol Cell. 2014;54(5):728-36.

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Note: Technical data last updated: Sep 1, 2026.