CAS No. 1450655-76-1
Batch:
Purity:99.00
Chemical Structure
Check the
CPI-169
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[1-(1-ethylsulfonylpiperidin-4-yl)ethyl]-N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methylindole-3-carboxamide | |
|---|---|---|
| CAS Number | 1450655-76-1 | |
| Molecular Formula |
C27H36N4O5S |
|
| Molecular Weight (MW) | 528.66 | |
| SMILES | CCS(=O)(=O)N1CCC(CC1)C(C)N2C(=C(C3=CC=CC=C32)C(=O)NCC4=C(C=C(NC4=O)C)OC)C | |
| InChIKey | LHGUZCKPFXXVPV-UHFFFAOYSA-N |
CPI-169 is a potent and selective small-molecule inhibitor of histone methyltransferase EZH2 and its homolog EZH1. By blocking the catalytic subunit of Polycomb Repressive Complex 2 (PRC2), CPI-169 decreases tri-methylation of histone H3 at lysine 27 (H3K27me3), leading to the transcriptional activation of epigenetically silenced tumor suppressor genes and suppressed cancer cell proliferation. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(189.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.