CAS No. 3042878-82-7

Batch: Purity:98.77
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Cpd. 37 Chemical Structure
Chemical Structure
Check the Cpd. 37 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[4-chloro-3-(trifluoromethyl)phenyl]-3-(4-morpholin-4-ylbut-1-ynyl)-6-[5-(trifluoromethyl)-1H-pyrazol-3-yl]phenol
CAS Number 3042878-82-7
Molecular Formula

C25H20ClF6N3O2
Molecular Weight (MW) 543.89
InChIKey ROQZCPAUTWKVGO-UHFFFAOYSA-N

Biological Activity

MYC-IN-3 (Cpd. 37) is an alkynyl-substituted phenylpyrazole derivative that acts as an inhibitor of MYC function by disrupting the MYC/MAX protein-protein interaction. By preventing the MYC/MAX complex from binding to target gene promoter DNA, it suppresses downstream MYC-driven transcriptional programs. This inhibition leads to marked antiproliferative effects across multiple cancer cell lines and suppresses tumor growth in animal models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (183.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 25 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Madden SK, et al. Mol Cancer. 2021;20(1):3.

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Note: Technical data last updated: Sep 1, 2026.