CAS No. 865317-32-4
Batch:
Purity:98.10
Chemical Structure
Check the
CP681301
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-(5-cyclobutyl-1H-pyrazol-3-yl)-2-[4-(dimethylamino)phenyl]acetamide | |
|---|---|---|
| CAS Number | 865317-32-4 | |
| Molecular Formula |
C17H22N4O |
|
| Molecular Weight (MW) | 298.38 | |
| InChIKey | PGTNTDKBRSQDNM-UHFFFAOYSA-N |
CP681301 is a brain-permeable small-molecule inhibitor targeting cyclin-dependent kinase 5 (Cdk5). By selectively inhibiting Cdk5 kinase activity, the compound disrupts downstream oncogenic signaling pathways essential for cancer stem cell maintenance. This targeted inhibition suppresses stem cell marker expression and decreases cellular proliferation, leading to marked antiproliferative and anti-tumor responses in ex vivo mouse xenograft tumor models.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
60 mg/mL
(201.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 15 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.