CAS No. 1217195-61-3

Batch: Purity:99.76
Check CoA
CP-31398 Dihydrochloride Chemical Structure
Chemical Structure
Check the CP-31398 Dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1217195-61-3
Molecular Formula

C22H28Cl2N4O
Molecular Weight (MW) 435.39
SMILES Cl.Cl.COC1=CC=C(C=C1)/C=C/C2=NC3=CC=CC=C3C(=N2)NCCCN(C)C

Ordering Information

Biological Activity

CP-Dihydrochloride is a small-molecule p53 modulating agent that stabilizes the active core domain conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Restoration of active p53 conformation enhances its DNA-binding capacity to p53 response elements without affecting p63 or phomologs. Consequently, this reactivated p53 pathway drives downstream transcriptional activation of target genes such as pand triggers apoptotic cascade responses in tumor cells. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 87 mg/mL (199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 87 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.