CAS No. 142715-48-8
Batch:
Purity:99.11
Chemical Structure
Check the
CP-100356 hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxyquinazolin-2-amine;hydrochloride | |
|---|---|---|
| CAS Number | 142715-48-8 | |
| Molecular Formula |
C31H36N4O6.ClH |
|
| Molecular Weight (MW) | 597.10 | |
| InChIKey | WWCHXVYTCMPAMV-UHFFFAOYSA-N |
CP-100356 hydrochloride is an orally active dual inhibitor of multidrug resistance protein 1 (MDR1/P-gp) and breast cancer resistance protein (BCRP). By blocking ATP-binding cassette (ABC) efflux transporter function, it suppresses the transport of substrates such as calcein-AM and prazosin across cellular membranes. This inhibition attenuates active drug efflux, increasing intracellular drug accumulation and modulating xenobiotic disposition and multidrug resistance pathways. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(167.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.