CAS No. 630-94-4

Batch: Purity:99.98
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Corynoxeine Chemical Structure
Chemical Structure
Check the Corynoxeine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name methyl (E)-2-[(3R,6'R,7'S,8'aS)-6'-ethenyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate
CAS Number 630-94-4
Molecular Formula

C22H26N2O4
Molecular Weight (MW) 382.45
SMILES COC=C(C1CC2C3(CCN2CC1C=C)C4=CC=CC=C4NC3=O)C(=O)OC
InChIKey MUVGVMUWMAGNSY-KAXDATADSA-N

Biological Activity

Corynoxeine is a natural alkaloid that acts as an ERK1/2 signaling inhibitor. By blocking the phosphorylation and activation of the ERK1/2 extracellular signal-regulated kinase pathway, it suppresses PDGF-BB-induced vascular smooth muscle cell proliferation. Downstream, this inhibition reduces cellular remodeling and proliferation associated with vascular diseases, highlighting its potential protective role in vascular smooth muscle cell dysfunction.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 76 mg/mL (198.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 7 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.