CAS No. 18797-79-0
Batch:
Purity:99.77
Chemical Structure
Check the
Corynoline
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 18797-79-0 | |
|---|---|---|
| Molecular Formula |
C21H21NO5 |
|
| Molecular Weight (MW) | 367.40 | |
| SMILES | CC12C(CC3=CC4=C(C=C3C1N(CC5=C2C=CC6=C5OCO6)C)OCO4)O |
Corynoline is a naturally occurring isoquinoline alkaloid that exhibits anti-inflammatory, anti-tumor, and hepatoprotective activities. It acts as a bioactive modulator targeting key intracellular signaling networks, including the NF-kB pathway, to suppress pro-inflammatory cytokine expression and downstream inflammatory cascades. Through these regulatory mechanisms, corynoline inhibits cell proliferation and attenuates inflammatory responses across multiple preclinical cellular models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
10 mg/mL
(27.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
22 mg/mL
(59.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
10 mg/mL
(27.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.