CAS No. 6020-18-4
Batch:
Purity:99.37
Chemical Structure
Check the
Coptisine chloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 6020-18-4 | |
|---|---|---|
| Molecular Formula |
C19H14NO4.Cl |
|
| Molecular Weight (MW) | 355.77 | |
| SMILES | C1C[N+]2=C(C=C3C=CC4=C(C3=C2)OCO4)C5=CC6=C(C=C51)OCO6.[Cl-] |
Coptisine chloride is an isoquinoline alkaloid that acts as an uncompetitive indoleamine 2,3-dioxygenase (IDO) inhibitor. By suppressing IDO activity, it modulates tryptophan metabolism and attenuates immunosuppressive signaling in the tumor microenvironment. Downstream, coptisine inhibits the NF-κB and MAPK signaling pathways, suppressing pro-inflammatory cytokine expression, inducing apoptosis, and inhibiting proliferation in hepatoma and leukemia cells. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
3 mg/mL
(8.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.