CAS No. 1402152-13-9
Batch:
Purity: 98.53
Chemical Structure
Check the
Copanlisib dihydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydro-1H-imidazo[1,2-c]quinazolin-5-ylidene]pyrimidine-5-carboxamide;dihydrochloride | |
|---|---|---|
| CAS Number | 1402152-13-9 | |
| Molecular Formula |
C23H28N8O4.2ClH |
|
| Molecular Weight (MW) | 553.44 | |
| InChIKey | KWVVOPDWPMORCQ-UHFFFAOYSA-N |
Biological Activity
Copanlisib dihydrochloride is a selective pan-class I PI3K inhibitor targeting PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ. By blocking class I PI3K signaling, it suppresses downstream AKT/mTOR pathway activation, leading to inhibition of cellular proliferation and induction of apoptosis. In preclinical studies, copanlisib exhibits robust antitumor activity across cell-line–derived and patient-derived xenograft tumor models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.