CAS No. 1384860-29-0

Batch: Purity:99.19
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Conteltinib(CT-707) Chemical Structure
Chemical Structure
Check the Conteltinib(CT-707) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[[2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-N-propan-2-ylbenzenesulfonamide
CAS Number 1384860-29-0
Molecular Formula

C32H45N9O3S
Molecular Weight (MW) 635.83
InChIKey NPJCURIANJMFEO-UHFFFAOYSA-N

Biological Activity

Conteltinib (CT-707) is a potent multikinase inhibitor targeting focal adhesion kinase (FAK; IC50 = 1.6 nM), anaplastic lymphoma kinase (ALK), and proline-rich tyrosine kinase 2 (Pyk2). By inhibiting FAK activation, conteltinib impairs downstream PDPK1-AKT pathway signaling, leading to suppressed cancer cell proliferation, attenuated xenograft tumor growth, and overcoming resistance to tyrosine kinase inhibitors.[1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 25 mg/mL (39.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Wang DD, et al. Mol Cancer Ther. 2016;15(12):2916-2925.

[2] Liang C, et al. Curr Cancer Drug Targets. 2019;19(8):655-665.

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Note: Technical data last updated: Sep 1, 2026.