CAS No. 6090-95-5

Conduritol B epoxide Chemical Structure
Chemical Structure
Check the Conduritol B epoxide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1S,2R,3S,4S,5R,6R)-7-oxabicyclo[4.1.0]heptane-2,3,4,5-tetrol
CAS Number 6090-95-5
Molecular Formula

C6H10O5
Molecular Weight (MW) 162.14
InChIKey ZHMWOVGZCINIHW-FTYOSCRSSA-N

Ordering Information

Biological Activity

Conduritol B epoxide is an irreversible covalent inhibitor of acid β-glucocerebrosidase (GCase). Pharmacological blockade of GCase disrupts lysosomal glycosphingolipid catabolism, resulting in cellular accumulation of glucosylceramide. This lysosomal impairment downstream increases neuronal α-synuclein accumulation. Consequently, conduritol B epoxide is widely utilized to model the neuropathological mechanisms of neuronopathic Gaucher disease and related synucleinopathies. [1][2]

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Note: Technical data last updated: Sep 1, 2026.