CAS No. 209986-17-4
Batch:
Purity:98.85
Chemical Structure
Check the
Compound E
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]-N-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]propanamide | |
|---|---|---|
| CAS Number | 209986-17-4 | |
| Molecular Formula |
C27H24F2N4O3 |
|
| Molecular Weight (MW) | 490.50 | |
| InChIKey | JNGZXGGOCLZBFB-IVCQMTBJSA-N |
Biological Activity
Compound E is a potent inhibitor of γ-secretase that suppresses γ-secretase-mediated cleavage of Notch. By inhibiting γ-secretase activity, it blocks the Notch signaling pathway and suppresses the production of β-amyloid(40) and β-amyloid(42) peptides. This targeted blockade disrupts downstream Notch-dependent functions, significantly impairing gonadotropin-dependent follicle growth and halting progression to the preovulatory stage of development. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
98 mg/mL
(199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.