CAS No. 168425-64-7
Batch:
Purity:99.51
Chemical Structure
Check the
Compound 401
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-morpholin-4-ylpyrimido[2,1-a]isoquinolin-4-one | |
|---|---|---|
| CAS Number | 168425-64-7 | |
| Molecular Formula |
C16H15N3O2 |
|
| Molecular Weight (MW) | 281.31 | |
| SMILES | C1COCCN1C2=CC(=O)N3C=CC4=CC=CC=C4C3=N2 | |
| InChIKey | BVRDQVRQVGRNHG-UHFFFAOYSA-N |
Compound 401 is a synthetic inhibitor targeting DNA-dependent protein kinase (DNA-PK) and mechanistic target of rapamycin (mTOR). Inhibition of DNA-PK disrupts cellular DNA double-strand break repair mechanisms, whereas suppression of mTOR signaling inhibits downstream phosphorylation of S6 kinase 1 and Akt, leading to impaired protein synthesis, cell growth regulation, and metabolic pathway modulation within the AKT/mTOR and DNA repair cascades. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
7 mg/mL
(24.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.