CAS No. 546-97-4
Batch:
Purity:99.88
Chemical Structure
Check the
Columbin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 546-97-4 | |
|---|---|---|
| Molecular Formula |
C20H22O6 |
|
| Molecular Weight (MW) | 358.39 | |
| SMILES | CC12CCC3C(=O)OC(CC3(C1C4C=CC2(C(=O)O4)O)C)C5=COC=C5 |
Columbin is a diterpenoid furanolactone with potential anti-inflammatory activity. It target-modulates inflammatory signaling through attenuation of the NF-kB pathway, leading to down-regulated expression of pro-inflammatory mediators including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). This regulatory pathway control suppresses cellular inflammatory responses and mitigates inflammatory damage in biological models.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
72 mg/mL
(200.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
71 mg/mL
(198.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.