CAS No. 532-91-2

Batch: Purity:99.72
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Coixol Chemical Structure
Chemical Structure
Check the Coixol product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 532-91-2
Molecular Formula

C8H7NO3
Molecular Weight (MW) 165.15
SMILES COC1=CC2=C(C=C1)NC(=O)O2

Biological Activity

Coixol (6-methoxybenzoxazolone) is a naturally derived bioactive benzoxazolinone that acts as a central muscle relaxant with anticonvulsant and anti-inflammatory properties. It modulates key cellular response pathways, including the regulation of NF-kB and MAPK signaling cascades involved in inflammatory mediator expression. Through these regulatory actions, Coixol suppresses pro-inflammatory signaling and attenuates central nervous system excitability, serving as a functional probe for neuromuscular studies. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 33 mg/mL (199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Kyriakis JM, et al. Physiol Rev. 2012;92(2):689-737.

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Note: Technical data last updated: Sep 1, 2026.