CAS No. 906439-72-3
Batch:
Purity:98.12
Chemical Structure
Check the
COH34
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol | |
|---|---|---|
| CAS Number | 906439-72-3 | |
| Molecular Formula |
C18H15NOS |
|
| Molecular Weight (MW) | 293.38 | |
| InChIKey | SFUAIBHPGDRCFL-UHFFFAOYSA-N |
COH34 is a potent, selective inhibitor of poly(ADP-ribose) glycohydrolase (PARG). By binding to the catalytic domain of PARG, it prevents poly(ADP-ribose) degradation and prolongs PARylation at sites of DNA damage. This persistence traps key DNA repair factors at lesions, impairing single- and double-strand break repair pathways and triggering cytotoxicity. COH34 serves as a valuable small-molecule tool for exploring PARG biology and targeted cancer therapies. [1][2]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
59 mg/mL
(201.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
59 mg/mL
(201.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.