CAS No. 1534358-79-6
Batch:
Purity:99.35
Chemical Structure
Check the
COH000
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | dimethyl (1R,4S)-1-[(1R)-1-anilino-2-(4-methylphenyl)ethyl]-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate | |
|---|---|---|
| CAS Number | 1534358-79-6 | |
| Molecular Formula |
C25H25NO5 |
|
| Molecular Weight (MW) | 419.47 | |
| SMILES | CC1=CC=C(C=C1)CC(C23C=CC(O2)C(=C3C(=O)OC)C(=O)OC)NC4=CC=CC=C4 | |
| InChIKey | UFPINDDCTUCUSA-DFIYOIEZSA-N |
COH000 is an allosteric, covalent, and irreversible ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) inhibitor with an IC50 offor SUMOylation in vitro. By binding to a cryptic site on the enzyme, it blocks the formation of the SUMO-E1 thioester intermediate and impairs global cellular SUMOylation. Consequently, COH000 suppresses cancer cell proliferation and promotes apoptosis, demonstrating potent antitumor activity across various cancer models. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(119.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.