CAS No. 1190932-38-7
Batch:
Purity:99.87
Chemical Structure
Check the
COH-29
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[4-(3,4-dihydroxyphenyl)-5-phenyl-1,3-thiazol-2-yl]-3,4-dihydroxybenzamide | |
|---|---|---|
| CAS Number | 1190932-38-7 | |
| Molecular Formula |
C22H16N2O5S |
|
| Molecular Weight (MW) | 420.44 | |
| SMILES | C1=CC=C(C=C1)C2=C(N=C(S2)NC(=O)C3=CC(=C(C=C3)O)O)C4=CC(=C(C=C4)O)O | |
| InChIKey | LGGDLPSXAGQFSG-UHFFFAOYSA-N |
COH-29 is a potent inhibitor of ribonucleotide reductase (RNR) that selectively targets the RRM1/RRM2 subunit complex. By inhibiting enzymatic RNR activity, COH-29 disrupts essential DNA replication and repair pathways, resulting in S-phase cell cycle arrest, accumulation of DNA double-strand breaks, and robust suppression of cancer cell proliferation across multiple tumor models.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
40 mg/mL
(95.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.