CAS No. 7646-79-9
Batch:
Purity:99.97
Chemical Structure
Check the
Cobalt chloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | cobalt(2+) dichloride | |
|---|---|---|
| CAS Number | 7646-79-9 | |
| Molecular Formula |
Cl2Co |
|
| Molecular Weight (MW) | 129.84 | |
| InChIKey | GVPFVAHMJGGAJG-UHFFFAOYSA-L |
Biological Activity
Cobalt chloride is a widely used hypoxia-mimetic agent that induces cellular hypoxia signaling pathways. It triggers apoptosis in PC12 cells through the generation of reactive oxygen species accompanied by AP-1 activation. Additionally, cobalt chloride induces delayed cardiac preconditioning in vivo by selectively activating HIF-1α, AP-1, and iNOS signaling, and serves as an inducer for animal models of high-altitude polycythemia. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
13 mg/mL
(100.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 13 mg/mL (Please dissolve in pure water, avoid PBS or saline, as it may not clarify.) |
| Ethanol | 5 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.