CAS No. 1374640-70-6

Batch: Purity:99.97
Check CoA
Rociletinib (CO-1686) Chemical Structure
Chemical Structure
Check the Rociletinib (CO-1686) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide
CAS Number 1374640-70-6
Molecular Formula

C27H28F3N7O3
Molecular Weight (MW) 555.55
SMILES CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F)OC
InChIKey HUFOZJXAKZVRNJ-UHFFFAOYSA-N

Biological Activity

Rociletinib (CO-1686) is an irreversible, mutant-selective EGFR inhibitor that targets EGFR L858R/T790M and wild-type EGFR. By covalently binding to mutant EGFR, it selectively suppresses EGFR autophosphorylation and downstream AKT and ERK signaling pathways. This targeted inhibition impairs cellular proliferation and induces apoptosis in non-small cell lung cancer models harboring EGFR resistance mutations. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (180.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Free Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.

Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.

Reference

[1] Walter AO, et al. Cancer Discov. 2013;3(12):1404-15.

Jump to

Note: Technical data last updated: Sep 1, 2026.