CAS No. 115066-14-3
Batch:
Purity:99.55
Chemical Structure
Check the
CNQX
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 7-nitro-2,3-dioxo-1,4-dihydroquinoxaline-6-carbonitrile | |
|---|---|---|
| CAS Number | 115066-14-3 | |
| Molecular Formula |
C9H4N4O4 |
|
| Molecular Weight (MW) | 232.15 | |
| SMILES | [O-][N+](=O)C1=CC2=C(NC(=O)C(=O)N2)C=C1C#N | |
| InChIKey | RPXVIAFEQBNEAX-UHFFFAOYSA-N |
CNQX -cyano--nitroquinoxaline-2,-dione) is a potent, competitive AMPA receptor and kainate receptor antagonist. It also acts as an antagonist at the glycine modulatory site on the NMDA receptor complex. By blocking ionotropic glutamate receptors, CNQX inhibits excitatory neurotransmission in central neurons, demonstrating neuroprotective activity against ischemic insult and suppressing seizure-like epileptiform activity in hippocampal circuits. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
46 mg/mL
(198.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.