CAS No. 1846570-31-7
Batch:
Purity:99.67
Chemical Structure
Check the
CM272
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-methoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amine | |
|---|---|---|
| CAS Number | 1846570-31-7 | |
| Molecular Formula |
C28H38N4O3
|
|
| Molecular Weight (MW) | 478.63 | |
| SMILES | CC1=CC=C(O1)C2=NC3=CC(=C(C=C3C(=C2)NC4CCN(CC4)C)OC)OCCCN5CCCC5 | |
| InChIKey | RLQLKZTYUYIWDB-UHFFFAOYSA-N |
CM-272 is a first-in-class dual reversible inhibitor targeting G9a (IC50 = 8 nM), GLP (IC50 = 2 nM), DNMT1 (IC50 = 382 nM), DNMT3A (IC50 = 85 nM), and DNMT3B (IC50 = 1200 nM). Dual inhibition of G9a/GLP histone methyltransferases and DNA methyltransferases leads to epigenetic reprogramming, inducing immunogenic cell death and suppressing tumor progression to prolong survival in in vivo models of haematological malignancies.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
96 mg/mL
(200.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 96 mg/mL |
| Water | Insoluble |
| DMSO |
96 mg/mL
(200.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 96 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.