CAS No. 14984-68-0

Batch: Purity:99.64
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Cloperastine hydrochloride Chemical Structure
Chemical Structure
Check the Cloperastine hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 14984-68-0
Molecular Formula

C20H24ClNO.HCl
Molecular Weight (MW) 366.32
SMILES C1CCN(CC1)CCOC(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl

Biological Activity

Cloperastine hydrochloride (HT-11) is a central antitussive agent endowed with antihistaminic activity that functions as a histamine H1 receptor antagonist. By inhibiting histamine H1 receptor-mediated signaling pathways, cloperastine suppresses central cough reflex generation and attenuates peripheral allergic responses. Blockade of H1 receptor activation dampens downstream inflammatory cascades, contributing to its combined antitussive and antihistaminic pharmacological profile. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 73 mg/mL (199.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Shimamura T, et al. Nature. 2011;475(7354):65-70.

[2] Leurs R, et al. Clin Exp Allergy. 2002;32(4):489-98.

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Note: Technical data last updated: Sep 1, 2026.