CAS No. 85187-37-7
Batch:
Purity:99.75
Chemical Structure
Check the
Cloperastine fendizoate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine;2-(4-hydroxy-3-phenylbenzoyl)benzoic acid | |
|---|---|---|
| CAS Number | 85187-37-7 | |
| Molecular Formula |
C20H24ClNO.C20H14O4 |
|
| Molecular Weight (MW) | 648.19 | |
| InChIKey | PXZFKAKWSHBDCP-UHFFFAOYSA-N |
Biological Activity
Cloperastine fendizoate is a central antitussive agent and potassium channel inhibitor targeting hERG K+ channels. Downstream, blockade of hERG potassium channels inhibits cardiac repolarizing currents and modulates cellular excitability, while its peripheral action desensitizes afferent nerves in the tracheobronchial region. These mechanisms contribute to the attenuation of cough reflex pathways and modulation of membrane conductance in responsive tissues. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
33 mg/mL
(50.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.