Clinical Trials

Numerous clinical trials spanning Early Phase 1 through Phase 4 evaluate the therapeutic applications of clonidine, predominantly sponsored by academic medical centers, university hospitals, and independent investigators. Encompassing completed, active, recruiting, terminated, and withdrawn protocols, these studies investigate indications including hypertension, postoperative pain, diabetic neuropathy, lumbosacral radiculopathy, and growth hormone deficiency, while also highlighting its utility in regional anesthesia sedation and labor epidural analgesia.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00262470 ACTIVE_NOT_RECRUITING
Tachycardia; Chronic Orthostatic Intolerance
Satish R. Raj
 1997-04 PHASE1; PHASE2
NCT06780865 NOT_YET_RECRUITING
Chronic Kidney Disease(CKD); Nocturnal Hypertension
Shanghai Institute of Hypertension
 2025-01-30
NCT07567495 NOT_YET_RECRUITING
Cesarean Delivery; Cesarean Delivery; Neuraxial Opioids; Spinal Anesthesia for Cesarean Section; Dexmedetomidine; Clonidine; Postoperative Analgesia
Columbia University
 2026-06 PHASE4
NCT07360301 NOT_YET_RECRUITING
Well-Being, Psychological; Psychedelic Experiences
University of Wisconsin, Madison
 2026-09 PHASE1
NCT05091242 RECRUITING
Emergence Delirium
Rigshospitalet, Denmark
 2021-10-25 PHASE2; PHASE3
NCT07092566 RECRUITING
Renal Carcinoma; Nephrectomy / Methods; Pain Management
Wake Forest University Health Sciences
 2025-11-14 PHASE3
NCT03121261 ACTIVE_NOT_RECRUITING
Inguinal Hernia; Spinal Anesthesia
University Hospital Dubrava
 2017-05-01 PHASE4
NCT01530373 RECRUITING
Hot Flashes; Breast Cancer
University of Arkansas
 2012-02 PHASE2
NCT07097493 NOT_YET_RECRUITING
Knee Arthroplasty, Total
Wake Forest University Health Sciences
 2027-02 PHASE4
NCT04877093 RECRUITING
PTSD; Posttraumatic Stress Disorder; Sleep
Wake Forest University Health Sciences
 2023-06-01 PHASE3
NCT07350252 RECRUITING
Osteo Arthritis of the Knee
Region Skane
 2026-03-05 PHASE4
NCT05029726 RECRUITING
Lumbar Spinal Stenosis; Lumbar Disc Herniation; Lumbar Spondylolisthesis; Lumbar Spondylosis; Lumbar Radiculopathy; Lumbar Spine Instability; Synovial Cyst; Degenerative Disc Disease; Degenerative Spondylolisthesis; Degenerative Intervertebral Discs
John O'Toole
 2022-02-01 PHASE4
NCT06447194 WITHDRAWN
Degenerative Lumbar Spinal Stenosis; Degenerative Disc Disease; Degenerative Spondylolisthesis; Degenerative Disease
University of Maryland, Baltimore
 2025-10-01 PHASE1; PHASE2
NCT07256938 NOT_YET_RECRUITING
Arthroscopic Shoulder Surgeries
Assiut University
 2025-12 PHASE4
NCT07044609 NOT_YET_RECRUITING
Attention-deficit/Hyperactivity Disorder; Oppositional Defiant Disorder in Children
Las Vegas Medical Research, LLC DBA Vector Clinical Trials
 2025-07 PHASE4
NCT05416840 NOT_YET_RECRUITING
Hypertension
Jing Liu
 2024-01 PHASE4
NCT04934228 RECRUITING
Blood Pressure; Diabetes; Obesity; Insulin Resistance; Diuretics Drug Reactions; Sympathetic Nerve Activity
University of Kansas Medical Center
 2021-07-01 PHASE1
NCT07313371 RECRUITING
Cocaine Use Disorder; Crack Abuse or Dependence
University of Sao Paulo General Hospital
 2026-01-28 PHASE4
NCT05824832 RECRUITING
Pain, Postoperative
Loyola University
 2023-02-28 PHASE4
NCT07461376 RECRUITING
Pediatric Sedation; Clonidine Sedation; Ketamine Sedation
Cairo University
 2025-04-15
NCT04828226 COMPLETED
Major Depressive Disorder; Catatonia; Bipolar Disorder; Delirium Postseizure
Insel Gruppe AG, University Hospital Bern
 2021-04-27 PHASE4
NCT07062497 RECRUITING
Hernia, Umbilical; Clonidine; Pain, Postoperative; Ambulatory Surgical Procedures; Regional Anesthesia Block
Universidade Federal do Rio de Janeiro
 2025-01-07 PHASE2; PHASE3
NCT07131657 COMPLETED
Nerve Block; Upper Extremity Surgery
PHARMAFINA
 2025-09-02 PHASE2
NCT05943613 UNKNOWN
Postoperative Pain
Assiut University
 2023-12-01 PHASE1
NCT05360953 SUSPENDED
Posttraumatic Stress Disorder
Charite University, Berlin, Germany
 2022-06-17 PHASE2
NCT04423627 COMPLETED
Hypertension, Systolic; Stiffness, Aortic
University of Iowa
 2021-06-01 EARLY_PHASE1
NCT06230081 ACTIVE_NOT_RECRUITING
Osteoarthritis of the Knee or Hip
Region Skane
 2024-02-01
NCT05355597 TERMINATED
Musculoskeletal Diseases; Soft Tissue Mass
Atlantic Health System
 2021-01-27 PHASE2
NCT06287151 COMPLETED
Surgery
Nationwide Children's Hospital
 2023-08-09
NCT06781632 COMPLETED
Healthy; Nerve Block
PHARMAFINA
 2024-11-13 PHASE1
NCT05592379 COMPLETED
Healthy; Psychedelic Experiences; Sleep
University of Wisconsin, Madison
 2023-11-07 PHASE1
NCT04902859 UNKNOWN
Retinopathy of Prematurity; Pain, Procedural; Premature Infant Disease
Region Örebro County
 2022-04-25 PHASE4
NCT01876355 UNKNOWN
Delirium
Deventer Ziekenhuis
 2024-01 PHASE3
NCT03092011 ACTIVE_NOT_RECRUITING
Neonatal Abstinence Syndrome
The Cooper Health System
 2018-02-21 PHASE4
NCT05790044 UNKNOWN
Postoperative Pain
Assiut University
 2023-10-01
NCT06507410 UNKNOWN
Clonidine; Propofol; Sedation; Colonoscopy
Tanta University
 2024-07-20
NCT05560230 COMPLETED
Endometriosis; Postoperative Pain; Pain, Acute; Pain, Acute Postoperative
University of Aarhus
 2022-10-03 PHASE4
NCT05029050 UNKNOWN
Delirium; Cognitive Decline; Frailty
Oslo University Hospital
 2022-01-17 PHASE4
NCT04786873 COMPLETED
Growth Hormone Deficiency
AEterna Zentaris
 2021-11-16 PHASE3
NCT06180941 UNKNOWN
Upper Limb Injury
Assiut University
 2023-12
NCT03396588 COMPLETED
Neonatal Abstinence Syndrome
Henrietta Bada
 2017-12-07 PHASE3
NCT06137924 UNKNOWN
Pain, Postoperative; Nausea, Postoperative; Vomiting, Postoperative; Analgesia; Opioid Use
Universidad Simón Bolívar
 2023-12-02 PHASE3
NCT05614648 TERMINATED
Lumbosacral Radiculopathy
Sollis Therapeutics, Inc.
 2023-06-19 PHASE3
NCT05575219 COMPLETED
Withdrawal; Therapeutic Substance
The University of Texas Health Science Center, Houston
 2022-10-08 PHASE4
NCT07297888 COMPLETED
Pain
Shri Guru Ram Rai Institute of Medical and Health Sciences
 2022-07-20
NCT05848531 UNKNOWN
Sickle Cell Disease; Vaso-occlusive Pain Episode in Sickle Cell Disease
Centre Hospitalier Universitaire Saint Pierre
 2023-04-25 PHASE4
NCT03653832 COMPLETED
Critical Illness
University of Edinburgh
 2018-12-10 PHASE3
NCT06031090 UNKNOWN
Post Spinal Anesthesia Shivering
Zagazig University
 2023-03-05 PHASE2
NCT05487196 COMPLETED
Pregnancy Related
Grace Lim, MD, MS
 2022-09-28 PHASE2
NCT03109795 TERMINATED
Anxiety; Hypertension
University of Iowa
 2017-04-10 PHASE4
NCT04648020 TERMINATED
Chemoradiotherapy-Induced Severe Oral Mucositis
Monopar Therapeutics
 2021-02-11 PHASE2; PHASE3
NCT04603911 COMPLETED
Breast Cancer
Tufts Medical Center
 2020-12-04 PHASE2
NCT02505204 SUSPENDED
Ventral Hernia Repair
Makassed General Hospital
 2015-08-01
NCT02592915 UNKNOWN
Intraoperative Neurophysiological Monitoring; Pain Management
Queen Fabiola Children's University Hospital
 2015-10 PHASE3
NCT03119038 WITHDRAWN
Osteoarthritis; Degenerative Joint Disease
Rush University Medical Center
 2016-04-30 PHASE4
NCT02268448 COMPLETED
Cutaneous Nerves CNS Itch
University of Minnesota
 2015-07 PHASE1
NCT04263064 COMPLETED
Male Circumcision
Medical University of South Carolina
 2020-03-06 EARLY_PHASE1
NCT05371574 UNKNOWN
Blood Loss
Uwakwe Emmanuel Chijioke
 2022-01-03 PHASE1
NCT04465565 WITHDRAWN
Growth Hormone Deficiency
Rabin Medical Center
 2020-12
NCT04186299 WITHDRAWN
Symptomatic Irreversible Pulpitis
University of California, San Francisco
 2021-08 PHASE4
NCT02628626 COMPLETED
Fecal Incontinence; Bile Acid Malabsorption
Mayo Clinic
 2015-11 PHASE3
NCT03537612 TERMINATED
Scoliosis
Dr. Jean A. Ouellet, MD, FRCSC
 2018-06-22 PHASE3
NCT02539693 UNKNOWN
Pilonidal Sinus
Makassed General Hospital
 2016-10
NCT04758936 UNKNOWN
Delirium; Critical Illness
Erasme University Hospital
 2021-02-01 PHASE4
NCT05536362 COMPLETED
Colon Cancer; Post Operative Pain
Egymedicalpedia
 2021-02-01 PHASE1
NCT04564430 UNKNOWN
Polydactyly Toe; Thumb Hypoplasia; Trigger Finger; Polydactyly; Fingers; Osteomyelitis of Hindfoot; Osteomyelitis of Midfoot; Congenital Talipes Equinovarus; Congenital Talipes Calcaneus; Tarsal Coalition; Club Foot; Clubfoot; Congenital Knee Deformity; Leg Length Inequality in Children; Flatfoot; Hollow Foot; Congenital Valgus Foot Deformity; Polydactylia; Polysyndactyly; Syndactyly; Thumb Aplasia; Congenital Hand and Foot Deformity; Subungual Exostosis; Finger Deformity; Toe Deformity; Osteomyelitis of the Foot; Calcaneus Deformity of Foot; Congenital Hand Deformity; Hand Deformities, Congenital; Valgus Foot Deformity; Toe Joint Deformity; Capsulitis of MTP Joint
Odense University Hospital
 2021-03-01 PHASE4
NCT03725930 COMPLETED
Child Preschool
University Hospital, Lille
 2019-03-26 PHASE3
NCT03342950 TERMINATED
Neuralgia Peripheral
Terence J. Coderre
 2019-02-19 PHASE2
NCT04737473 UNKNOWN
Opioids; Clinical Trial; Anesthesia; Gynecology; Surgery
University of Yaounde 1
 2020-01-06
NCT03552068 COMPLETED
Parkinson's Disease; Mpulse Control Disorders
Hospices Civils de Lyon
 2019-05-15 PHASE2
NCT02891798 COMPLETED
Pain
Brian Williams
 2016-10 PHASE3
NCT04833218 UNKNOWN
Traumatic Brain Injury
Minia University
 2020-01-31 EARLY_PHASE1
NCT02543944 COMPLETED
Drug Dependence
University of Arkansas
 2016-02 PHASE2; PHASE3
NCT04032691 WITHDRAWN
Healthy Volunteers
Weill Medical College of Cornell University
 2019-08-27 EARLY_PHASE1
NCT02570503 TERMINATED
Osteoarthritis, Knee
Virginia Commonwealth University
 2015-10 PHASE4
NCT04530903 UNKNOWN
Proctological Surgery
Centre Hospitalier Universitaire Saint Pierre
 2020-09-09 PHASE4
NCT00748059 COMPLETED
Autonomic Nervous System Diseases; Orthostatic Hypotension; Dopamine Beta-Hydroxylase Deficiency; Orthostatic Intolerance
Vanderbilt University Medical Center
 1996-12 PHASE1
NCT03147092 UNKNOWN
Hypertension; Blood Pressure
Centro Neurológico de Pesquisa e Reabiitação, Brazil
 2018-02-01 EARLY_PHASE1
NCT03770013 COMPLETED
Postoperative Pain
Aswan University Hospital
 2019-01-01
NCT02276495 COMPLETED
Pain Management
University of California, Irvine
 2015-01-01
NCT01983462 TERMINATED
Obesity; Prehypertension; Hypertension
Gary L. Pierce
 2013-10 PHASE2
NCT03670160 COMPLETED
Neonatal Abstinence Syndrome
University of Tennessee Medical Center
 2018-10-01 PHASE2
NCT02740127 COMPLETED
Malignant Neoplasms of Male Genital Organs
M.D. Anderson Cancer Center
 2016-06 PHASE3
NCT04030572 TERMINATED
Neuro-Degenerative Disease; Cancer
Weill Medical College of Cornell University
 2019-12-10 EARLY_PHASE1
NCT03727100 COMPLETED
Lumbosacral Radiculopathy
Sollis Therapeutics, Inc.
 2018-10-16 PHASE3
NCT03017430 COMPLETED
Opioid Withdrawal
St. Petersburg Bekhterev Research Psychoneurological Institute
 2014-01 PHASE4
NCT02249039 COMPLETED
Mechanical Ventilation Complication
Johns Hopkins University
 2015-09 PHASE1
NCT02655965 COMPLETED
Locoregional Analgesia in Breast Surgery
Jules Bordet Institute
 2016-05 PHASE3
NCT04026074 COMPLETED
Knee Arthropathy; Hip Arthritis; Fractures, Closed
Medical University of Graz
 2019-07-26 PHASE4
NCT03155646 COMPLETED
Transversus Abdominis Plane Block
Assiut University
 2017-06-10 PHASE2; PHASE3
NCT03057015 UNKNOWN
Postoperative Pain
University of Vermont
 2017-05-22 PHASE4
NCT03477994 COMPLETED
Delirium on Emergence
Ain Shams University
 2018-12-01
NCT03762317 TERMINATED
Neonatal Abstinence Syndrome
Hennepin County Medical Center, Minneapolis
 2018-04-30 PHASE4
NCT02563821 COMPLETED
Anesthesia, Epidural
University Hospital, Limoges
 2015-11-05 PHASE3
NCT02509273 TERMINATED
Sedation in Intensive Care
University of Erlangen-Nürnberg Medical School
 2016-05 PHASE3
NCT03679052 COMPLETED
Shivering
Ain Shams University
 2018-03-01 PHASE4
NCT02543801 COMPLETED
Total Hip and Knee Arthroplasty
Kootenai Health
 2016-01-25 PHASE4
NCT03520543 COMPLETED
Healthy Controls
Hospices Civils de Lyon
 2018-05-21 PHASE1
NCT03667352 COMPLETED
Condition: Abdominal Bone Flap Cranioplasty; Focus of Study: Perioperative Analgesia
Dhritiman Chakrabarti
 2017-07-15 PHASE4
NCT02439281 TERMINATED
Postoperative Pain
Mihaela Visoiu
 2015-05
NCT02466373 COMPLETED
Delirium; Critical Illness
Deventer Ziekenhuis
 2016-12 PHASE3
NCT03007966 COMPLETED
Nerve Block; Herniorrhaphy; Regional Anesthesia
Wake Forest University Health Sciences
 2017-01-30 PHASE2
NCT03124082 UNKNOWN
Postoperative Pain
University of Parma
 2017-01-04 PHASE4
NCT03704376 COMPLETED
Anterior Cruciate Ligament Injury
The University of Texas Health Science Center, Houston
 2016-02-01 PHASE4
NCT01956604 TERMINATED
Delirium
Oslo University Hospital
 2014-04-10 PHASE2
NCT01598896 TERMINATED
Cannabis Dependence; Marijuana Dependence
Mclean Hospital
 2012-05 PHASE2; PHASE3
NCT02643355 COMPLETED
Substance Withdrawal Syndrome
Hennepin Healthcare Research Institute
 2015-11
NCT03018171 UNKNOWN
Labor Pain
San Giovanni Calibita Fatebenefratelli Hospital
 2017-01 PHASE4
NCT02365961 COMPLETED
Hip Dysplasia; Femoroacetabular Impingement; Acetabular Labrum Tear
The Hawkins Foundation
 2015-04 PHASE4
NCT02530151 COMPLETED
Femoracetabular Impingement; Pain, Postoperative
Northwestern University
 2015-11 PHASE4
NCT02778178 COMPLETED
Pain, Postoperative
University Hospital, Lille
 2016-05-02 PHASE4
NCT03117140 COMPLETED
Anesthesia, Local
Melinda Seering
 2013-12 PHASE4
NCT01931215 COMPLETED
Postoperative Pain
Benno Rehberg-Klug
 2013-09 PHASE4
NCT01846221 COMPLETED
Labor Pain
Columbia University
 2014-07-15 PHASE4
NCT00223717 COMPLETED
Hypertension
Vanderbilt University
 2001-01 PHASE1
NCT02812368 WITHDRAWN
Autism Spectrum Disorder
Ohio State University
 2016-08 PHASE2
NCT02773602 UNKNOWN
Postoperative Pain
The University of Texas Health Science Center, Houston
 2011-05 PHASE4
NCT01785693 COMPLETED
Peripheral Arterial Occlusive Disease
University Hospital, Clermont-Ferrand
 2013-01-30 PHASE4
NCT02643251 COMPLETED
Painful Diabetic Neuropathy; Diabetic Neuropathy; Neuropathy
BioDelivery Sciences International
 2015-12 PHASE2
NCT02953210 UNKNOWN
Pain, Postoperative; Anesthesia Complication; Nausea; Vomiting; Ileus Paralytic; Hemodynamic Instability
Federal University of São Paulo
 2016-11 PHASE4
NCT01851486 WITHDRAWN
Experimental Pain Perception
Rambam Health Care Campus
 2013-01
NCT03207022 COMPLETED
Brachial Plexus Blockade
Cork University Hospital
 2014-06-11
NCT01813149 TERMINATED
Complex Regional Pain Syndrome (CRPS)
The Cleveland Clinic
 2012-08
NCT02545530 UNKNOWN
Renal Dialysis
Peking University People's Hospital
 2015-05
NCT03174067 COMPLETED
Opioid Withdrawal; Opioid-use Disorder
St. Joseph's Health Centre Toronto
 2013-03 PHASE4
NCT02371759 COMPLETED
Diabetes Mellitus; Local Anesthesia
University of Belgrade
 2013-06 PHASE3
NCT01902108 COMPLETED
Post-operative Pain
St Joseph University, Beirut, Lebanon
 2013-01 PHASE4
NCT02548806 COMPLETED
Healthy
Valerio Therapeutics
 2015-09 PHASE1
NCT01986751 TERMINATED
Pain
University of Alabama at Birmingham
 2014-01 PHASE1; PHASE2
NCT02361476 COMPLETED
Psychomotor Agitation
Rigshospitalet, Denmark
 2015-01 PHASE4
NCT02769390 COMPLETED
Postoperative Pain
Federal University of Minas Gerais
 2015-07 PHASE2
NCT02733757 COMPLETED
Anesthesia
Federal University of Minas Gerais
 2013-05 PHASE2
NCT02365727 WITHDRAWN
Knee Osteoarthritis
The Hawkins Foundation
 2015-04 PHASE4
NCT02355158 COMPLETED
Painful Diabetic Neuropathy; Diabetes
BioDelivery Sciences International
 2014-06 PHASE2
NCT02444559 COMPLETED
Healthy
Zealand University Hospital
 2015-05 PHASE2
NCT02239627 TERMINATED
Back Pain
West Virginia University
 2014-09
NCT01188421 COMPLETED
Opioid Related Disorders; Opioid Dependence; Opioid Addiction
Johns Hopkins University
 2010-10 PHASE1; PHASE2
NCT01112878 WITHDRAWN
Shoulder Arthroscopy; Knee Arthroscopy
Cedars-Sinai Medical Center
 2015-06 PHASE4
NCT02550444 COMPLETED
Pregnancy
University of Sao Paulo General Hospital
 2015-04
NCT01862250 COMPLETED
Encephalopathy, Hypoxic-Ischemic
Johns Hopkins University
 2013-10-03 PHASE1; PHASE2
NCT02068027 COMPLETED
Painful Diabetic Neuropathy; Diabetic Neuropathy; Neuropathy
BioDelivery Sciences International
 2014-03 PHASE2
NCT01322048 COMPLETED
Brain Injuries; Craniocerebral Trauma; Trauma, Nervous System; Traumatic Brain Injury
Vanderbilt University
 2011-08 PHASE2
NCT01734551 COMPLETED
Neonatal Abstinence Syndrome
Henrietta Bada
 2011-09 PHASE4
NCT00930072 TERMINATED
Vasospasm
University of Washington
 2009-04 PHASE2
NCT02067078 COMPLETED
Total Knee Arthroplasty; Pain; Nerve Blocks
Regionshospitalet Silkeborg
 2014-02 PHASE4
NCT02181543 COMPLETED
Is an Only Child
Professor Fernando Figueira Integral Medicine Institute
 2013-08 PHASE3
NCT02128451 COMPLETED
Amputation Stumps
Tanta University
 2014-04 PHASE4
NCT01385748 COMPLETED
Oral Mucositis
Valerio Therapeutics
 2010-04 PHASE2
NCT02541071 COMPLETED
Intrusive Memories
Charite University, Berlin, Germany
 2013-11
NCT01179009 COMPLETED
Depressive Disorder, Treatment-Resistant
Washington University School of Medicine
 2012-04
NCT02096744 COMPLETED
Healthy
Boehringer Ingelheim
 2014-03 PHASE1
NCT00580151 TERMINATED
Pain; Anxiety
The University of Texas Medical Branch, Galveston
 2004-06
NCT02362256 COMPLETED
Opiate Addiction
Vilnius University
 2014-05
NCT02410460 COMPLETED
Rhytidoplasty
Mercy Facial Plastic Surgery Center
 2013-09
NCT01082874 COMPLETED
Cardiovascular Disease
Hamilton Health Sciences Corporation
 2010-07 PHASE3
NCT02324413 COMPLETED
Negative Behaviour Change
Richard Beringer
 2013-10 PHASE3
NCT00130091 COMPLETED
Hernia, Inguinal; Hydrocele
Children's Hospital of Eastern Ontario
 2009-09 PHASE2
NCT01643434 UNKNOWN
Hypertension
Instituto do Coracao
 2012-08 PHASE4
NCT01963299 COMPLETED
Indication for Surgery of the Posterior Segment Under Locoregional Anaesthesia
Centre Hospitalier Universitaire Dijon
 2013-08-16 PHASE2
NCT01856517 TERMINATED
Septic Shock
Direction Centrale du Service de Santé des Armées
 2013-08 PHASE2; PHASE3
NCT01796483 COMPLETED
Parkinson Disease
Hospices Civils de Lyon
 2012-10
NCT01761916 COMPLETED
Preeclampsia
Instituto Materno Infantil Prof. Fernando Figueira
 2013-01 PHASE4
NCT01784250 UNKNOWN
Anxiety
CES University
 2012-08 PHASE2
NCT01293149 WITHDRAWN
Other Reconstructive Surgery
Nationwide Children's Hospital
 2011-04 PHASE2
NCT01415895 COMPLETED
Back Pain; Lower Back Pain; Cervical Pain
Annette C. Toledano MD
 2011-07 PHASE2
NCT01759524 COMPLETED
Bimalleolar Fractures of the Ankle.; Sciatic Nerve Block.; Saphenous Nerve Block.; Post Operative Analgesia Duration.
Cork University Hospital
 2011-10 PHASE4
NCT03065933 TERMINATED
Bipolar Disorder, Mania
Mclean Hospital
 2012-01 PHASE4
NCT01559012 COMPLETED
Hyperemesis Gravidarum
A.O.U. Città della Salute e della Scienza
 2012-02 PHASE3
NCT01439126 COMPLETED
Attention Deficit Hyperactivity Disorder
Concordia Pharmaceuticals Inc., Barbados
 2011-08 PHASE4
NCT01677351 UNKNOWN
Pain; Arrythmia
Federal University of São Paulo
 2011-07 PHASE2
NCT00959062 COMPLETED
Respiration, Artificial; Critical Illness; Conscious Sedation; Deep Sedation
Hamilton Health Sciences Corporation
 2010-01 PHASE4
NCT01370811 COMPLETED
Sialorrhoea
Orient Pharma Co., Ltd.
 2011-08 PHASE2
NCT01139996 TERMINATED
Delirium
Memorial Health University Medical Center
 2010-05 PHASE4
NCT00884832 COMPLETED
Fecal Incontinence
Mayo Clinic
 2008-10 PHASE2
NCT01175668 TERMINATED
Neonatal Abstinence Syndrome
Baystate Medical Center
 2010-07
NCT01297335 COMPLETED
Hypertension
The Center for Clinical Research, Winston-Salem, NC
 2011-02 PHASE2
NCT01040429 COMPLETED
Chronic Fatigue Syndrome; Myalgic Encephalomyelitis
Oslo University Hospital
 2010-02 PHASE2
NCT01425658 COMPLETED
Post Operative Pain
Qazvin University Of Medical Sciences
 2011-08 PHASE1; PHASE2
NCT00585871 WITHDRAWN
Ventricular Tachycardia
James Martins
 2006-05
NCT01619436 COMPLETED
Glycemia During Coronary Artery Bypass Graft; Sedation During Pre-anesthetic Medication
Federal University of Juiz de Fora
 2011-01 PHASE4
NCT01052623 UNKNOWN
Ataxia Telangiectasia; Growth Failure
Johann Wolfgang Goethe University Hospital
 2010-01 PHASE4
NCT00535925 COMPLETED
Diabetic Nephropathy
University of Campania Luigi Vanvitelli
 2005-10 PHASE4
NCT00206986 COMPLETED
Schizophrenia
Birte Glenthoj
 2005-05
NCT01360450 TERMINATED
Neonatal Abstinence Syndrome
Johns Hopkins University
 2011-07 PHASE2; PHASE3
NCT01620112 COMPLETED
Fascicular Block; Motor Activity; Pain, Postoperative; Latency Period
Universidade Federal do Rio de Janeiro
 2009-02 PHASE2
NCT01042093 COMPLETED
Osteoarthritis,Knee
Towson Orthopaedic Associates
 2010-01
NCT01205204 WITHDRAWN
Full Term Pregnant Patients; Undergoing Lower Segment Caesarian Section
Pravara Institute of Medical Sciences University
 2010-08
NCT01597427 COMPLETED
Anesthesia
Federal University of São Paulo
 2009-03 PHASE2
NCT00858845 COMPLETED
Heart Failure
University of California, Los Angeles
 2008-05 PHASE4
NCT01136278 COMPLETED
Mood Disorder; Substance-Related Disorders; Amphetamine-Related Disorders
University Hospital, Basel, Switzerland
 2010-07 PHASE1
NCT01015807 COMPLETED
Hyperalgesia, Secondary
University of Washington
 2009-11
NCT01454609 COMPLETED
Pain; Postoperative
Jawaharlal Institute of Postgraduate Medical Education & Research
 2009-01 PHASE2
NCT01507701 COMPLETED
Chronic Fatigue Syndrome
Oslo University Hospital
 2010-01
NCT00723190 COMPLETED
Attention Deficit Hyperactivity Disorder
Shionogi
 2008-01 PHASE3
NCT00983125 COMPLETED
Labour
University Hospital, Clermont-Ferrand
 2009-08 PHASE4
NCT00860925 COMPLETED
Cardiovascular Disease
McMaster University
 2009-05 PHASE4
NCT00695565 COMPLETED
Painful Diabetic Neuropathy
Arcion Therapeutics Inc
 2008-05 PHASE2
NCT00678379 COMPLETED
Postoperative Pain
Vanderbilt University Medical Center
 2008-04 PHASE3
NCT00335582 UNKNOWN
Heart Disease
University Health Network, Toronto
 2006-06 PHASE4
NCT00661895 COMPLETED
Hypertension
Creighton University
 2005-08 PHASE4
NCT00661063 UNKNOWN
Diabetic Neuropathy; Pain
Irmandade da Santa Casa de Misericordia de Sao Paulo
 2008-04 PHASE3
NCT00588354 TERMINATED
Lumbar and Other Intervertebral Disc Disorders With Radiculopathy
Mayo Clinic
 2006-10
NCT00641329 COMPLETED
ADHD
Addrenex Pharmaceuticals, Inc.
 2008-02 PHASE3
NCT00329511 WITHDRAWN
Hypertension
Afshan B. Hameed, M.D.
 2004-09
NCT00860899 COMPLETED
Analgesia; Pain; Systemic Inflammatory Stress Response
University Hospital Dubrava
 2007-12 PHASE4
NCT00672347 COMPLETED
Postoperative Pain
Federal University of Minas Gerais
 2008-07 PHASE1; PHASE2
NCT00556959 COMPLETED
Attention Deficit Disorder With Hyperactivity
Addrenex Pharmaceuticals, Inc.
 2007-10 PHASE3
NCT00370838 COMPLETED
Tic Disorders; Tourette Syndrome
Harvey S. Singer
 2007-02 PHASE4
NCT01638052 COMPLETED
Tympanomastoid Surgery; Cochlear Implant; Mastoidectomy; Cholesteatoma
Ann & Robert H Lurie Children's Hospital of Chicago
 2006-02 PHASE2
NCT00350532 COMPLETED
Pain
Wake Forest University Health Sciences
 2004-09 PHASE2
NCT00349921 COMPLETED
Pain
Wake Forest University Health Sciences
 2004-08 PHASE2
NCT00226096 COMPLETED
CVA (Cerebrovascular Accident); Cerebral Hemorrhage; Intracranial Hemorrhages
The George Institute
 2005-11
NCT00638729 COMPLETED
Anxiety; Pain
University Hospital Schleswig-Holstein
 2005-08
NCT01075490 UNKNOWN
Spinal Anesthesia; Neonates
University Hospital, Montpellier
 2006-11 PHASE4
NCT00134420 COMPLETED
Loss of Chromosome 18q; Growth Hormone Deficiency
The University of Texas Health Science Center at San Antonio
 2001-02 PHASE3
NCT00730054 COMPLETED
Acute Pain; Respiration; Sedation
Oslo University Hospital
 2005-02 PHASE1; PHASE2
NCT00194974 WITHDRAWN
Pregnancy Toxemia; Hypertension; Proteinuria
Weill Medical College of Cornell University
 2004-07 PHASE1; PHASE2
NCT00032955 COMPLETED
Heroin Dependence; Morphine Dependence; Substance Withdrawal Syndrome
University of California, Los Angeles
 2001-02 PHASE3
NCT02177461 COMPLETED
Hypertension
Boehringer Ingelheim
 2000-04 PHASE4
NCT00032968 COMPLETED
Heroin Dependence; Morphine Dependence; Substance Withdrawal Syndrome
University of California, Los Angeles
 2001-01 PHASE3
NCT00000279 COMPLETED
Opioid-Related Disorders; Substance-Related Disorders
Yale University
 1994-09 PHASE2
NCT00417443 WITHDRAWN
Postoperative Hyperalgesia
Cambridge University Hospitals NHS Foundation Trust
 2007-12 PHASE3
NCT00691795 WITHDRAWN
Labor Pain
Columbia University
 PHASE4
NCT00318760 COMPLETED
Cocaine Abuse; Heroin Abuse
National Institute on Drug Abuse (NIDA)
 2005-06-14 PHASE1
NCT00312416 COMPLETED
Ocular Physiology; Regional Blood Flow
Medical University of Vienna
 2004-02 PHASE4
NCT00356226 COMPLETED
Ascitic Cirrhosis; Hyperactivation of Sympathetic Nervous System
CHU de Charleroi
 2000-10
NCT00031395 COMPLETED
Attention Deficit Disorder With Hyperactivity
University of Cincinnati
 1999-09 PHASE3
NCT00437996 COMPLETED
Normal Pregnancy
Hospices Civils de Lyon
 2007-02 PHASE3
NCT00166686 WITHDRAWN
Treatment-Related Cancer
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
 PHASE1; PHASE2
NCT00287326 TERMINATED
Pain
University of North Carolina, Chapel Hill
 2006-01 PHASE3
NCT00295308 COMPLETED
Opioid-Related Disorders
National Institute on Drug Abuse (NIDA)
 2005-11-08 PHASE1
NCT00279253 COMPLETED
Physiology
Medical University of Vienna
 2004-03 PHASE4
NCT00152750 UNKNOWN
Tourette's Syndrome; Attention Deficit Hyperactivity Disorder
University Health Network, Toronto
 2006-09 PHASE4
NCT00510016 COMPLETED
Neonatal Abstinence Syndrome
National Institute on Drug Abuse (NIDA)
 2002-07 PHASE2
NCT00414921 COMPLETED
Attention Deficit Hyperactivity Disorder
University of Cincinnati
 2003-09 PHASE2

(data from https://clinicaltrials.gov, updated on 2025-10-08)

Check the Clonidine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Clonidine functions as a selective agonist at presynaptic alpha-2 adrenergic receptors, which inhibits adenylate cyclase activity and decreases intracellular cyclic AMP accumulation. This downstream suppression of central sympathetic outflow and presynaptic norepinephrine release reduces vascular tone and central nervous system excitability, underlying its clinical efficacy in treating hypertension, pain, and procedural sedation.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.