CAS No. 303-49-1
Batch:
Purity:99.72
Chemical Structure
Check the
Clomipramine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine | |
|---|---|---|
| CAS Number | 303-49-1 | |
| Molecular Formula |
C19H23ClN2 |
|
| Molecular Weight (MW) | 314.85 | |
| InChIKey | GDLIGKIOYRNHDA-UHFFFAOYSA-N |
Clomipramine is a tricyclic antidepressant that acts as a non-selective monoamine reuptake inhibitor, potently blocking serotonin (5-HT) reuptake with an IC50 of. By inhibiting presynaptic monoamine transporters, it elevates synaptic concentrations of serotonin and norepinephrine in the central nervous system. This potentiated monoaminergic neurotransmission modulates downstream neural signaling pathways, influencing neurotransmitter signaling and central nervous system functions. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
63 mg/mL
(200.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 63 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.