CAS No. 88416-50-6

Batch: Purity:98
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Clodronate disodium tetrahydrate Chemical Structure
Chemical Structure
Check the Clodronate disodium tetrahydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 88416-50-6
Molecular Formula

CH10Cl2Na2O10P2
Molecular Weight (MW) 360.92
SMILES C(P(=O)(O)[O-])(P(=O)(O)[O-])(Cl)Cl.O.O.O.O.[Na+].[Na+]

Biological Activity

Clodronate disodium tetrahydrate is a non-nitrogenous bisphosphonate that targets osteoclast activity and calcium metabolism. It is intracellularly metabolized into non-hydrolyzable ATP analogs, disrupting mitochondrial function and inducing apoptosis in osteoclasts and macrophages. Consequently, clodronate suppresses bone resorption and reduces soft tissue calcification, making it a key probe in bone biology and macrophage depletion studies. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 72 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Frith JC, et al. J Bone Miner Res. 1997;12(9):1358-67.

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Note: Technical data last updated: Sep 1, 2026.