CAS No. 105956-97-6
| IUPAC Name | 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid | |
|---|---|---|
| CAS Number | 105956-97-6 | |
| Molecular Formula |
C17H17ClFN3O3 |
|
| Molecular Weight (MW) | 365.79 | |
| SMILES | C1CC1N2C=C(C(=O)C3=CC(=C(C(=C32)Cl)N4CCC(C4)N)F)C(=O)O | |
| InChIKey | QGPKADBNRMWEQR-UHFFFAOYSA-N |
Clinafloxacin is a broad-spectrum fluoroquinolone antibiotic that functions as a dual inhibitor of bacterial DNA gyrase and topoisomerase IV, particularly in Streptococcus pneumoniae. By binding to these essential type II topoisomerases, clinafloxacin stabilizes enzyme-DNA cleavage complexes, thereby inhibiting bacterial DNA replication and transcription. This dual-targeting mechanism effectively prevents DNA supercoiling resolution and promotes double-strand DNA break accumulation, culminating in potent bactericidal activity. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| 5%TFA | 3.02 mg/mL |
| DMSO |
0.03 mg/mL
(0.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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