CAS No. 57645-91-7
Batch:
Purity:99.87
Chemical Structure
Check the
Clebopride malate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 57645-91-7 | |
|---|---|---|
| Molecular Formula |
C24H30ClN3O7 |
|
| Molecular Weight (MW) | 507.96 | |
| SMILES | COC1=CC(=C(C=C1C(=O)NC2CC[NH+](CC2)CC3=CC=CC=C3)Cl)N.C(C(C(=O)[O-])O)C(=O)O |
Clebopride malate is a substituted benzamide derivative that functions as a dopamine D2 receptor antagonist with gastroprokinetic and antiemetic properties. By blocking central and peripheral dopamine D2 receptors, it modulates dopaminergic signaling in the gastrointestinal tract and chemoreceptor trigger zone. This inhibition enhances gastrointestinal motility and gastric emptying, downstream attenuating nausea and vomiting associated with functional gastrointestinal disorders.
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(196.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 33 mg/mL |
| Ethanol | 12 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.