CAS No. 58001-44-8
Batch:
Purity:99.79
Chemical Structure
Check the
Clavulanic acid
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | |
|---|---|---|
| CAS Number | 58001-44-8 | |
| Molecular Formula |
C8H9NO5 |
|
| Molecular Weight (MW) | 199.16 | |
| InChIKey | HZZVJAQRINQKSD-PBFISZAISA-N |
Biological Activity
Clavulanic acid is a naturally occurring bacterial β-lactamase inhibitor. Its β-lactam ring irreversibly binds to the active site of serine β-lactamase enzymes, resulting in competitive enzyme inactivation. By blocking β-lactamase-mediated degradation, clavulanic acid prevents antibiotic resistance and enhances the antibacterial efficacy of co-administered β-lactam antibiotics, such as amoxicillin, against β-lactamase-producing bacterial strains. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
40 mg/mL
(200.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 40 mg/mL |
| Ethanol | 2 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.