CAS No. 307002-71-7

Batch: Purity:99.84
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CL-82198 Chemical Structure
Chemical Structure
Check the CL-82198 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(4-morpholin-4-ylbutyl)-1-benzofuran-2-carboxamide
CAS Number 307002-71-7
Molecular Formula

C₁₇H₂₂N₂O₃
Molecular Weight (MW) 302.37
SMILES O=C(NCCCCN1CCOCC1)C2=CC3=CC=CC=C3O2
InChIKey KUJQEQAVMNFFAO-UHFFFAOYSA-N

Ordering Information

Biological Activity

CL-82198 is a selective, orally bioavailable matrix metalloproteinase-13 (MMP-13) inhibitor. By targeting MMP-13, CL-82198 prevents the proteolytic activation of proMMP-9 and attenuates progressive extracellular matrix remodeling in diseased tissue explants. Downstream, pharmacological inhibition of reactive oxygen species–induced MMP-13 activity using CL-82198 suppresses glucose-mediated neurotoxicity, preventing sensory axon degeneration and restoring sensory function in preclinical models of diabetic neuropathy. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
1 mg 5 mg 10 mg
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 60 mg/mL (198.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 60 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.