CAS No. 194423-06-8
Batch:
Purity:99.79
Chemical Structure
Check the
CL-387785 (EKI-785)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[4-(3-bromoanilino)quinazolin-6-yl]but-2-ynamide | |
|---|---|---|
| CAS Number | 194423-06-8 | |
| Molecular Formula |
C18H13BrN4O |
|
| Molecular Weight (MW) | 381.23 | |
| SMILES | CC#CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br | |
| InChIKey | BTYYWOYVBXILOJ-UHFFFAOYSA-N |
CL-387785 is an irreversible and selective epidermal growth factor receptor (EGFR) inhibitor (IC50 370 pM). By covalently binding to the ATP-binding pocket of EGFR, CL-387785 blocks receptor autophosphorylation and suppresses downstream EGFR signaling through the MAPK and PI3K/AKT pathways. Consequently, this targeted inhibition impairs cancer cell proliferation and triggers apoptosis in EGFR-overexpressing tumor cells. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(199.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
76 mg/mL
(199.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
63 mg/mL
(165.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.