CAS No. 338404-52-7
Batch:
Purity:99.43
Chemical Structure
Check the
CITCO
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (E)-1-[6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]-N-[(3,4-dichlorophenyl)methoxy]methanimine | |
|---|---|---|
| CAS Number | 338404-52-7 | |
| Molecular Formula |
C19H12Cl3N3OS |
|
| Molecular Weight (MW) | 436.74 | |
| SMILES | ClC1=CC=C(C=C1)C2=C(\C=N\OCC3=CC=C(Cl)C(=C3)Cl)[N]4C=CSC4=N2 | |
| InChIKey | ZQWBOKJVVYNKTL-AUEPDCJTSA-N |
Biological Activity
CITCO is a potent and selective constitutive androstane receptor (CAR) agonist with an EC50 ofand exhibits 50-fold selectivity for CAR over PXR. Upon binding CAR, CITCO promotes nuclear translocation of the receptor to trigger target gene expression, such as CYP2B6. Consequently, CAR signaling regulates xenobiotic clearance, energy homeostasis, and neural stem cell proliferation. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
87 mg/mL
(199.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.