CAS No. 86393-32-0

Batch: Purity:99.93
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Ciprofloxacin hydrochloride hydrate Chemical Structure
Chemical Structure
Check the Ciprofloxacin hydrochloride hydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;hydrate;hydrochloride
CAS Number 86393-32-0
Molecular Formula

C17H18FN3O3.HCl.H2O
 
Molecular Weight (MW) 385.82
SMILES C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O.O.Cl
InChIKey ARPUHYJMCVWYCZ-UHFFFAOYSA-N

Biological Activity

Ciprofloxacin hydrochloride hydrate is a broad-spectrum fluoroquinolone antibiotic that targets bacterial DNA gyrase and topoisomerase IV. By inhibiting these essential enzymes, it blocks bacterial DNA replication, transcription, repair, and recombination. This disruption leads to the accumulation of double-stranded DNA breaks and ultimately induces rapid bactericidal cell death across diverse Gram-negative and Gram-positive bacterial strains. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 8 mg/mL (20.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Drlica K, et al. Microbiol Mol Biol Rev. 1997;61(3):377-92.

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Note: Technical data last updated: Sep 1, 2026.