CAS No. 118-10-5
Batch:
Purity:98.77
Chemical Structure
Check the
Cinchonine(LA40221)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 118-10-5 | |
|---|---|---|
| Molecular Formula |
C19H22N2O |
|
| Molecular Weight (MW) | 294.4 | |
| SMILES | C=CC1CN2CCC1CC2C(C3=CC=NC4=CC=CC=C34)O |
Cinchonine is a natural cinchona alkaloid that acts as a P-glycoprotein inhibitor. It effectively reverses multidrug resistance by blocking P-glycoprotein-mediated drug efflux, thereby significantly increasing the intracellular accumulation of substrate chemotherapeutics such as paclitaxel. In P-glycoprotein-positive cancer cells, cinchonine enhances chemotherapy-induced cytotoxicity, suppresses ABC transporter transport activity, and restores cellular sensitivity to antineoplastic treatment. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 4 mg/mL |
| DMSO |
2 mg/mL
(6.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | 12 mg/mL |
| DMSO |
9 mg/mL
(30.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.