CAS No. 85-79-0
Batch:
Purity:99.66
Chemical Structure
Check the
Cinchocaine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide | |
|---|---|---|
| CAS Number | 85-79-0 | |
| Molecular Formula |
C20H29N3O2 |
|
| Molecular Weight (MW) | 343.46 | |
| SMILES | CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NCCN(CC)CC | |
| InChIKey | PUFQVTATUTYEAL-UHFFFAOYSA-N |
Biological Activity
Cinchocaine (Dibucaine) is a long-acting local anesthetic that acts as a voltage-gated Na+ channel blocker. It inhibits serum cholinesterase and delays anoxic depolarization in human cortical slices during simulated ischemic conditions. Additionally, cinchocaine induces apoptosis in SK-N-MC human neuroblastoma cells and suppresses the growth of HL-60 promyelocytic leukemia cells, displaying broad cytotoxic and neuroprotective activity in cellular models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
69 mg/mL
(200.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 69 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.