CAS No. 199807-35-7
Batch:
Purity:99.50
Chemical Structure
Check the
Cilengitide trifluoroacetate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid;2,2,2-trifluoroacetic acid | |
|---|---|---|
| CAS Number | 199807-35-7 | |
| Molecular Formula |
C29H41F3N8O9 |
|
| Molecular Weight (MW) | 702.68 | |
| SMILES | CC(C)C1C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)N1C)CC2=CC=CC=C2)CC(=O)O)CCCN=C(N)N.C(=O)(C(F)(F)F)O | |
| InChIKey | WHJCSACXAPYNTG-LOPTWHKWSA-N |
Cilengitide is a potent integrin inhibitor targeting αvβ3 and αvβ5 receptors. By blocking integrin interactions with extracellular matrix ligands, it disrupts downstream focal adhesion kinase and AKT signaling pathways. This inhibition impairs endothelial cell adhesion, migration, and capillary tube formation, ultimately suppressing angiogenesis and promoting cell apoptosis in vascular and tumor models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(142.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 50 mg/mL |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(142.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 8 mg/mL |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(142.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 25 mg/mL |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(142.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 6.25 mg/mL |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(142.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Cilengitide trifluoroacetate Clinical Trials
- Cilengitide trifluoroacetate Solubility in DMSO
- Cilengitide trifluoroacetate Stock Solution
- Cilengitide trifluoroacetate Storage
- Cilengitide trifluoroacetate Stability
- Cilengitide trifluoroacetate Molecular Weight
- Cilengitide trifluoroacetate SMILES
- Cilengitide trifluoroacetate Chemical Structure (2D and 3D)
- Cilengitide trifluoroacetate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.