CAS No. 82009-34-5

Batch: Purity:99.95
Check CoA
Cilastatin Chemical Structure
Chemical Structure
Check the Cilastatin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 82009-34-5
Molecular Formula

C16H26N2O5S
Molecular Weight (MW) 358.45
SMILES CC1(CC1C(=O)NC(=CCCCCSCC(C(=O)O)N)C(=O)O)C

Biological Activity

Cilastatin is a renal dehydropeptidase-I (DHP-I) and leukotriene D4 dipeptidase inhibitor. By inhibiting renal DHP-I, it prevents the enzymatic degradation of carbapenem antibiotics such as imipenem in the proximal renal tubules, thereby enhancing their recovery and antibacterial efficacy. Additionally, inhibition of leukotriene D4 dipeptidase blocks the conversion of leukotriene D4 to leukotriene E4 in metabolic pathways. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 72 mg/mL (200.86 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 7 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Kahan FM, et al. J Antimicrob Chemother. 1983;12 Suppl D:1-35.

Jump to

Note: Technical data last updated: Sep 1, 2026.