CAS No. 834903-43-4
Batch:
Purity:99.96
Chemical Structure
Check the
CID16020046
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1,4-dihydropyrrolo[3,4-d]pyrazol-5-yl]benzoic acid | |
|---|---|---|
| CAS Number | 834903-43-4 | |
| Molecular Formula |
C25H19N3O4 |
|
| Molecular Weight (MW) | 425.44 | |
| SMILES | CC1=CC=C(C=C1)C2=NNC3=C2C(N(C3=O)C4=CC=C(C=C4)C(=O)O)C5=CC(=CC=C5)O | |
| InChIKey | VGUQVYZXABOXCX-UHFFFAOYSA-N |
CID16020046 is a selective GPR55 antagonist that inhibits GPR55 constitutive activity with an IC50 of 0.15 μM. By blocking GPR55 receptor activation, CID16020046 inhibits downstream L-α-lysophosphatidylinositol-mediated extracellular signal-regulated kinase (ERK) phosphorylation and intracellular calcium elevation. This blockade suppresses GPR55-dependent cellular migration and signaling phenotypes across various cell models while displaying weak activity against other GPCRs, ion channels, and kinases.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
85 mg/mL
(199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.